GNB3 overexpression causes obesity and metabolic syndrome

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GNB3 overexpression causes obesity and metabolic syndrome

The G-protein beta subunit 3 (GNB3) gene has been implicated in obesity risk; however, the molecular mechanism of GNB3-related disease is unknown. GNB3 duplication is responsible for a syndromic form of childhood obesity, and an activating DNA sequence variant (C825T) in GNB3 is also associated with obesity. To test the hypothesis that GNB3 overexpression causes obesity, we created bacterial ar...

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Obesity is a highly heritable condition and a risk factor for other diseases, including type 2 diabetes, cardiovascular disease, hypertension, and cancer. Recently, genomic copy number variation (CNV) has been implicated in cases of early onset obesity that may be comorbid with intellectual disability. Here, we describe a recurrent CNV that causes a syndrome associated with intellectual disabil...

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Obesity and Metabolic Syndrome

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Obesity, Metabolic Syndrome and Nutrition.

Over the span of the last decades there has been an alarming worldwide increase in childhood obesity [1] , which tends to track into adulthood [2] . Childhood obesity is associated with a significant risk for the development of type 2 diabetes, hypertension, dyslipidemia, metabolic syndrome, and is also a risk factor for early cardiovascular events. The timing of the obesity epidemic is paralle...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2017

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0188763